Each tablet contains 10mg of Acepromazine (as maleate).
Pronil is used as a tranquiliser, either alone or as part of an anaesthetic protocol, to aid in premedication, restraint, or the prevention of travel sickness.
Its sedative effect may last up to 24 hours, during which cardiac rate and rhythm, blood pressure, and oxygen saturation should be monitored.
- Cats/Dogs: 0.55–2.2 mg/kg orally (PO); use the lower end of the range where possible. May be combined with an anxiolytic medication such as gabapentin or trazodone.
- Procedure or Travel: 1 mg/kg PO, 45–60 minutes before the event.
- Adjunctive Treatment for Urethral Obstruction in Male Cats: 2.5 mg per cat PO every 8 hours (note: NOT mg/kg).
- Do not use in pregnant animals.
- Do not use on a long-term basis in individual animals.
Special Precautions
- Animals sedated with acepromazine may startle easily in response to sounds or other stimuli; approach with caution, as this can occasionally trigger aggression.
- Acepromazine is hypotensive; exercise particular care in hypovolaemic animals. Rehydration should precede administration.
- In some dogs, especially Boxers and other brachycephalic breeds, spontaneous fainting (syncope) may occur due to sinoatrial block from excessive vagal tone. A low dose should be used, and in cases with a history or suspicion of syncope, pre-treatment with atropine may help control dysrhythmia.
- Large dog breeds may be particularly sensitive to acepromazine; use the minimum effective dose.
Symptoms and Treatment of Overdose
- Accidental overdose may cause transient, dose-dependent hypotension.
Treatment includes:
- Discontinuing any other hypotensive agents
- Supportive care, such as intravenous infusion of warm isotonic saline
- Close monitoring of cardiovascular status
Remarks: Epinephrine (adrenaline) is contraindicated for treating hypotension caused by acepromazine overdose, as it may worsen systemic blood pressure depression.
Veterinary Partner. “Acepromazine (PromAce ®) - Veterinary Partner - VIN.” n.d. Accessed December 26, 2025. https://veterinarypartner.vin.com/doc/?id=4951450&pid=19239
MSD Veterinary Manual. “Tranquilizers, Sedatives, and Analgesics for Treatment of Animals ..” n.d. Accessed December 29, 2025. https://www.msdvetmanual.com/pharmacology/systemic-pharmacotherapeutics-of-the-nervous-system/tranquilizers-sedatives-and-analgesics-for-treatment-of-animals.
